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Vanderbilt Researchers and International Team Uncover Genes Linked to Multiple Sclerosis
Posted August 10, 2011

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Research doubles number of genes associated with the disease

An international team of scientists has identified 29 new genetic variants linked to multiple sclerosis, providing key insights into the biology of an important and very debilitating neurological disease.

Multiple sclerosis (MS), one of the most common neurological conditions among young adults, affects around 2.5 million individuals worldwide. It is a chronic disease that attacks the central nervous system (CNS), which includes the brain, spinal cord and optic nerves, and can cause severe symptoms such as paralysis or loss of vision.

Vanderbilt University Medical Center's Center for Human Genetics Research (CHGR) played an important role in the research published today in the journal Nature, which represents the largest MS genetics study ever undertaken and effectively doubles the number of genes known to be associated with the disease.

"We now know just how complex multiple sclerosis is," said Jonathan Haines, Ph.D., director of the CHGR and one of the principal researchers in this effort. "These new genes give us many new clues as to what is happening in MS and will guide our research efforts for years to come."

Researchers studied the DNA from 9,772 individuals with multiple sclerosis and 17,376 unrelated healthy controls. They were able to confirm 23 previously known genetic associations and identified a further 29 new genetic variants (and an additional five that are strongly suspected) conferring susceptibility to the disease.

Many genes implicated in the study are relevant to the immune system, shedding light onto the immunological pathways that underlie the development of multiple sclerosis.

One-third of the genes identified in the study have previously been implicated in playing a role in other autoimmune diseases such as Crohn's Disease and Type 1 diabetes, Haines said.

Previous studies have also suggested a link between vitamin D deficiency and an increased risk of multiple sclerosis; researchers in this study identified two genes involved in the metabolism of vitamin D, providing additional insight into a possible link between genetic and environmental risk factors.

The international team led by the Universities of Cambridge and Oxford, and funded by the Wellcome Trust, includes contributions from nearly 250 researchers as members of the International Multiple Sclerosis Genetics Consortium and the Wellcome Trust Case Control Consortium.

(Source: Vanderbilt University Medical Center)

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Online International Travel Insurance Quotes| Sunburst Virtual Travel Assistance Center| Home Page
Listings of Health Reports and Topics Around the World
Update on the Global Status on Polio |Measles Update 2011
 
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Click Here for Current Travel News and Travel Advisories on Facebook 
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The content of this page is protected by Copyright Laws. Do Not Copy. Legal Terms of Use

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INTERNATIONAL TRAVEL NEWS BRIEFS:
Please note that we at Sunburst Worldwide Insurance Services provides the International Travel News Briefs as a value-added service to our international clients and visitors of this website. Our International Travel News Briefs are updated frequently, in order to provide you with current and reliable news and events as quickly as we can. We have no control over the content of external websites, and links to various external news sources may become inactive at any time. We suggest that you bookmark our website and return frequently to check the current global news posted on our website.

Malaria Vaccine Trial Shows Promise October 21, 2011

Volcanic ash cloud: latest travel advice May 25, 2011
Here is a summary of the flight disruption caused as a volcanic ash cloud spreads from Iceland to British airspace, causing a number of airlines to put scheduled departures on hold across Scotland and northern England. more...

China: Beijing police halt unapproved church service April 11, 2011
Beijing police on Sunday detained dozens of worshippers from an unapproved Christian church who were trying to hold services in a public space after they were evicted from their usual place of worship, a parishioner said. more...

Faked Airline-Pilot Records Prompt India to Review Licenses March 25, 2011
India is reviewing the licenses of all of the 4,000-plus airline pilots working in the country, as police investigate at least 18 people suspected of using forged documents to win promotions or certification. more...

Tech bans study abroad travel to Mexico March 25, 2011
The Department of International Affairs officially has banned study abroad in Mexico through Texas Tech because of increased violence in the country caused by drug cartels. more...

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